Obstructive Jaundice Is Not Always Surgical!

Pneumatosis Intestinalis: Not Always a Surgical Indication

We present a case of pneumatosis intestinalis (PI) of the colon in the setting of inflammatory bowel disease that was treated with medical management rather than emergent surgery. While the reflex response to extraluminal air in the abdomen is abdominal exploration, consideration of the clinical context in which PI is discovered and an understanding of a complete differential diagnosis of the s...

Obstructive Jaundice

Obstructive Jaundice

Introduction Neonatal cholestasis is defined as prolonged elevation of serum levels of conjugated bilirubin beyond the first 14 days of life. Neonatal hyperbilirubinaemia is usually physiologic, unconjugated, and self-limited. Only 2–15% of neonates remain jaundiced past 2 weeks of life, and just 0.2–0.4% have cholestatic jaundice from either intrahepatic cholestasis or structural abnormalities...

Small is not always beautiful

Peer-to-peer content distribution systems have been enjoying great popularity, and are now gaining momentum as a means of disseminating video streams over the Internet. In many of these protocols, including the popular BitTorrent, content is split into mostly fixed-size pieces, allowing a client to download data from many peers simultaneously. This makes piece size potentially critical for perf...

Promiscuity is not always bad.

In the recent issue of Cell, Bonham et al. (2014) reveal that the sorting adaptor TIRAP regulates the assembly of the Myddosome upon Toll-like receptor activation from both the cell surface and endosomes through its promiscuous binding to lipids.